Abnormal microtubule dynamics disrupt nucleocytoplasmic transport in tau-mediated frontotemporal dementia.

Francesco Paonessa, Lewis Evans, Ravi Solanki, Delphine Larrieu, Selina Wray, John Hardy, Stephen P Jackson, Frederick J Livesey. 

Cell Reports, Jan 2019 P582-593.E5


Inhibition of acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway. 

Delphine Larrieu*, Emmanuelle Viré, Samuel Robson, Sophia Y. Breusegem, Tony Kouzarides and Stephen P. Jackson*. * Co-corresponding. 

Sci Signal. 2018 Jul 3;11(537).

Targeting of NAT10 enhances healthspan in a mouse model of human accelerated aging syndrome.  

Gabriel Balmus*, Delphine Larrieu*#, Ana C Barros, Casey Collins, Monica Abrudan, Mukerrem Demir, Nicola J Geisler, Christopher J. Lelliott, Jacqueline K. White, Natasha A Karp, James Atkinson, Andrea Kirton, Matt Jacobsen, Dean Clift, Raphael Rodriguez, Sanger Mouse Genetics Project, David J Adams, Stephen P Jackson#. *Co-authorship, #Co-corresponding. 

Nat Commun. 2018 Apr 27;9(1):1700.


A novel somatic mutation achieves partial rescue in a child with Hutchinson-Gilford progeria syndrome.

Bar DZ, Arlt MF, Brazier JF, Norris WE, Campbell SE, Chines P, Larrieu D, Jackson SP, Collins FS, Glover TW, Gordon LB.

J Med Genet. 2017 Mar;54(3):212-216.


Prelamin A impairs 53BP1 nuclear entry by mislocalizing NUP153 and disrupting the Ran gradient. 

Cobb AM, Larrieu D, Warren DT, Liu Y, Srivastava S, Smith AJ, Bowater RP, Jackson SP, Shanahan CM

Aging Cell. 2016 Jul 27


CRISPR-Cas9D10A nickase-based genotypic and phenotypic screening to enhance genome editing. 

W Chiang*, C le Sage*, D Larrieu, M Demir and Stephen P. Jackson. 

Sci Rep. 2016 Apr 15;6:24356.


Chemical inhibition of NAT10 corrects defects of laminopathic cells.

Larrieu D, Britton S, Demir M, Rodriguez R, Jackson SP

Science. 2014 May 2;344(6183):527-32


ING1 and ING2: multifaceted tumor suppressor genes.

Guérillon C, Larrieu D, Pedeux R. 

Cell Mol Life Sci. 2013 Oct;70(20):3753-72.


Sumoylation of ING2 regulates the transcription mediated by Sin3A.  

D Larrieu*, D Ythier*, R Binet, S Gazzeri, O Binda, E Brambilla, C Brambilla, O Gozani and R Pedeux.  *co-authorship. 

Oncogene. 2010 Nov 4;29(44):5946-56. 


ING2 controls the G1 to S phase transition by regulating p21 expression. 

Larrieu D, Ythier D, Brambilla C, Pedeux R. 

Cell Cycle. 2010 Oct 1;9(19):3984-90


ING2 controls DNA replication forks progression to maintain genome stability. 

D Larrieu, D Ythier, R Binet, C Brambilla, E Brambilla, S Sengupta and R Pedeux. 

EMBO Rep. 2009 Oct;10(10):1168-74


SharING out the roles in replicatING DNA.

Delphine Larrieu and Rémy Pedeux. 

Cell Cycle 2009 Nov 15;8(22):3623-4. 


WNT16B is a new marker of replicative senescence, SIPS and OIS that regulates p53 activity and the PI3K/AKT pathway.  

R Binet, D Ythier, AI Robles, M Collado, D Larrieu, C Fonti, E Brambilla, C Brambilla, M Serrano, CC. Harris, and R Pedeux. 

Cancer Res. 2009 Dec 15;69(24):9183-91. 


The new tumor suppressor genes ING: genomic structure and status in cancer.

Ythier D, Larrieu D, Brambilla C, Brambilla E, Pedeux R. 

Int J Cancer. 2008 Oct 1;123(7):1483-90. .