Honours and Awards
2018 Wellcome Trust Institutional Strategic Support Fund (ISSF)
2017 Wellcome Trust Sir Henry Dale fellowship
2014 Winner of the GlaxoSmithKline Discovery Fast-Track European Challenge
2014 3-year project grant from the Medical Research Council (£400,000)
2011 2-year long-term post-doctoral fellowship awarded by EMBO
2010 Second prize for the best PhD awarded by Joseph Fourier University of Grenoble
2007 3-year PhD fellowship awarded by the French Ministry of Research
2006 Master’s student honour fellowship awarded by the Joseph Fourier University of Grenoble
A key goal of my research is to better understand the roles and regulation of the nuclear envelope and how defects in these can cause human pathologies, especially premature ageing syndromes.
Since I established my lab at the CIMR, our goal has been to gain insights into the role of NAT10 and other factors that control nuclear envelope function. The lab is using chemical and genetic screens, and advanced proteomics, to reveal new regulatory mechanisms in these pathways, and biophysical approaches such as atomic force microscopy to investigate the mechanical properties of the nuclear envelope.
The long-term aim of the lab is to determine how subcellular processes including cytoskeletal dynamics and chromatin organization are coordinated to regulate the nuclear envelope function. As nuclear architecture defects are associated with human diseases such as premature aging syndromes, neurodegenerative disorders and muscular dystrophies, we will identify and characterize new pathways and mechanisms that can be modulated to improve the defects arising in these pathologies, revealing new potential therapeutic opportunities.
Oct 2017 - Present Principal investigator, Sir Henry Dale fellow, CIMR, Cambridge UK
Dec 2010 - May 2017 Postdoctoral research associate, Prof Steve Jackson, Cambridge UK
Oct 2007 - Oct 2010 PhD, Molecular Biology, Dr Rémy Pedeux, University of Grenoble France
Sept 2006 - Oct 2007 Research Assistant, Dr Rémy Pedeux. University of Grenoble France
Sept 2005 - Jun 2006 Research Assistant, Dr Taosheng HuangUniversity of California Irvine, USA