Honours and Awards

2018 Wellcome Trust Institutional Strategic Support Fund (ISSF)

2017 Wellcome Trust Sir Henry Dale fellowship 

2014  Winner of the GlaxoSmithKline Discovery Fast-Track European Challenge

2014  3-year project grant from the Medical Research Council (£400,000)

2011  2-year long-term post-doctoral fellowship awarded by EMBO

2010  Second prize for the best PhD awarded by Joseph Fourier University of Grenoble

2007  3-year PhD fellowship awarded by the French Ministry of Research 

2006  Master’s student honour fellowship awarded by the Joseph Fourier University of Grenoble

Research contributions

A key goal of my research is to better understand the roles and regulation of the nuclear envelope and how defects in these can cause human pathologies, especially premature ageing syndromes.

Since I established my lab at the CIMR, our goal has been to gain insights into the role of NAT10 and other factors that control nuclear envelope function. The lab is using chemical and genetic screens, and advanced proteomics, to reveal new regulatory mechanisms in these pathways, and biophysical approaches such as atomic force microscopy to investigate the mechanical properties of the nuclear envelope. 

The long-term aim of the lab is to determine how subcellular processes including cytoskeletal dynamics and chromatin organization are coordinated to regulate the nuclear envelope function. As nuclear architecture defects are associated with human diseases such as premature aging syndromes, neurodegenerative disorders and muscular dystrophies, we will identify and characterize new pathways and mechanisms that can be modulated to improve the defects arising in these pathologies, revealing new potential therapeutic opportunities.

Research career

Oct 2017 - Present       Principal investigator, Sir Henry Dale fellow, CIMR, Cambridge UK

Dec 2010 - May 2017 Postdoctoral research associate, Prof Steve Jackson, Cambridge UK

Oct 2007 - Oct 2010   PhD, Molecular Biology, Dr Rémy Pedeux, University of Grenoble France

Sept 2006 - Oct 2007  Research Assistant, Dr Rémy Pedeux. University of Grenoble France

Sept 2005 - Jun 2006  Research Assistant, Dr Taosheng HuangUniversity of California Irvine, USA