Current lab members

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Sophia Breusegem, PhD

Postdoctoral Research Associate

Funded by the Wellcome Trust

Background and research interests

I am a postdoctoral research associate in Delphine’s lab. While I obtained my PhD in Biophysics and Computational Biology, I now consider myself a cell biologist, fascinated by the intricate molecular processes that happen in our cells. I have particular expertise in quantitative, high-content and high-resolution fluorescent imaging. In Delphine’s lab I am interested in trying to understand the cell biology of the nuclear envelope in both health and disease. My previous research was in the field of membrane trafficking (retromer and renal ion transporters).

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Anne Janssen

Postdoctoral Research Associate

Funded by the Institutional Strategic Support Fund

Background and research interests

I am a postdoctoral research associate interested in the cell biology behind different types of progeria. During my PhD I worked on autophagic degradation of aggregates and during one of my side projects I got fascinated by the nucleus and how it can cope with different types of stress. I am therefore now interested in understanding how certain progeria mutations can lead to problems with maintaining nuclear integrity and how these impact other cellular processes. Previously, I gained expertise in live cell imaging to study cellular processes which I hope to utilise in my current projects.

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Jonathan Lam

PhD student

Funded by the BBSRC

Background and research interests

Having finished a Bachelor's degree in Natural Sciences from the University of Cambridge, specialising in Biochemistry, Jonathan proceeded to carry out a Master's degree at the same institution. Throughout this time he maintained an interest in molecular and cell biology, with a specific regard to how pathways were altered in relation to diseases. Before beginning his PhD with Delphine Larrieu at the Cambridge Institute for Medical Research, he had conducted shorter projects on a diverse range of subjects including X chromosome inactivation and the repair of DNA damage. He is currently interested in the mechanistic basis behind the phenotypic rescue of Hutchinson-Gilford Progeria cells and mice upon NAT10 inhibition.

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Andrew O’Connor

Research assistant

Background and research interests

I am a research assistant based in the Larrieu Lab. I have recently graduated with a BSc (Hons) in Biochemistry at Nottingham Trent University. My main interests revolve around the intricate cellular pathways keeping our cells functional and how these are affected in diseases such as cancer, dementia and rare genetic disorders. My previous research includes looking at interplay between the proteasome and mitochondria in neuronal cell lines. 


Past lab members

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Jack Byrne

MPhil student (November 2018-June 2019)

Cambridge Translational Biomedical Research MPhil

Jack will be starting his PhD at the LMB in Cambridge in September, we wish him the best of luck!


Alicia Barber

MPhil student (January-May 2018)

Cambridge Translational Biomedical Research MPhil

Alicia is now a Research Scientist at SUNY Polytechnic Institute (USA)