Human cells are highly organised and regulated, which is essential for the healthy function of tissues and organs. In recent years, it has become evident that one crucial part of the cell is a structure called the nuclear envelope (NE), which surrounds the cell nucleus – home to our DNA. This structure is crucial for maintaining normal nuclear architecture and cell function.
Dysfunction of the nuclear envelope leads to various human diseases, including cancer, muscular diseases, neurodegenerative syndromes and premature ageing syndromes called progeria.
The fact that nuclear envelope defects are associated with a broad range of human diseases, as well as with normal ageing, has triggered a strong interest in trying to correct the abnormal nuclei and associated defects in NE-associated syndromes, to improve cell “fitness” and patient survival. Unfortunately, there is no current cure for these diseases, and the available therapies mainly act by improving the symptoms of these patients. Our lab is working on identifying and characterising new mechanisms that improve nuclear envelope function in human syndromes.
Delphine Larrieu, PhD
Principal investigator, Wellcome Trust, Sir Henry Dale Fellow
Dr Delphine Larrieu completed her Master's degree in Integrative and Cell Biology at the University of California, Irvine (UCI) and at the University of Grenoble, France. She then carried out her PhD in the Remy Pedeux Laboratory at the Institute for Advanced Biosciences in Grenoble, working on tumour suppressor genes and their involvement in DNA replication and repair. She then undertook her postdoctoral research in the Steve Jackson Laboratory at the University of Cambridge, Gurdon Institute, with personal funding from EMBO and from the Medical Research Council (MRC). During her time as a postdoc, Delphine developed a strong interest in understanding nuclear envelope function and its links with disease, more specifically premature ageing. Upon being awarded a Wellcome Trust Sir Henry Dale fellowship, Delphine Larrieu set up her own lab at the Cambridge Institute for Medical Research to pursue her research in the field of nuclear envelope.
Read more about Delphine here